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Telomeres and their effects on cloning PDF Print E-mail
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Reference > Science
Written by Roshan Jha   
Friday, 10 April 2009 01:58

 

The word "Telomere" is derived from the Greek word "Telos" meaning end and "meros" meaning part. A telomere is a region at the end of the chromosomes which is made of repetitive DNA and plays an important role in the stability as well as the replication of cells. It is a part of the cell that prevents the destruction of the ends of the chromosomes. It is found in all the eukaryotic animals and in a few Prokaryotes. This enzyme is known as the "Telomerase reverse transcriptase".

 

The main function of the Telomeres is to prevent premature replication termination of the chromosomes. The Telomeres also act as a cell division limiters. The Telomerase shortening mechanism is responsible for shortening the lifespans of animals by limiting cells to a fixed number of divisions. Telomerase is an enzyme in the Telomeres that contain two molecules of Telomerase Reverse Transcriptase (TERT), two molecules of Telomorase RNA and two of dyskerin, too. The main function of Telomerase is to add Telomeres by the use of TERC. Telomerase lengthens the Telomeres after they have shortened following a cell division. It is also responsible for cancer.

 

Though very few healthy cells contain telomerase, most of the cancer cells contain telomerase. Hence, it can be stated that telomerase plays a part in the infinite doubling of the cancer cells.

 

Generally speaking, Cloning means creating copies of a product, an organism or the DNA of an animal. Biologically, it is the continuous process of creating genetically identical duplicates in microorganisms by asexual reproduction. When speaking in biotechnological terms, it is the process by which scientists create copies of Cells, DNA Fragments or of organisms.

 

The process of cloning requires a donor and an acceptor. The donor is the person who is going to give his DNA and his genetic codes to the clone. The acceptor will be the female who will give her womb for the development of the embryo.

 

The process starts when scientists take an unfertilized egg from the female and the nucleus of the donor that is extracted from cells taken from his body. The nucleus of the unfertilized egg is then extracted from the egg and the donor's nucleus is inserted in the egg. After this process is completed, the division of cells is started by sending an electric impulse or by the use of a chemical. The cell is allowed to divide for a few days and then, the embryo is placed in the acceptor's womb. It develops there as a normal embryo and when born, it has the exact genetic codes as the donors It is a carbon copy of the donor.

 

There is a considerable debate on whether cloning on Humans should be allowed or not as there are many risks involved in cloning.

 

The risks involved in cloning are as follows:

 

1.The process of cloning will start with the production of many dead babies and dying babies shortly after birth.

 

2.The Clone's genetic age will be the same of the donors due to same length of telomeres.

 

3.Cloning may lead to the end of humans due to inbreeding.

 

4.Clones have to bear unrealistic expectations of their social parents to mimic its biological father or mother to the fullest extent.

 

5.Human cloning may lead to cloning of famous personalities and may also lead to the sale of such clones. Buying and selling of human babies is unethical and should not be encouraged by any means.

 

6.Even the clones will need resources to live their life. This will further increase the consumption of resources on earth. Population, already is a serious problem in many countries.

 

Some of the benefits of cloning are:

 

1. Cloning can be used to protect species that are nearly extinct or recently extinct and can also be used to bring back extinct animals such as Dinosaurs.

 

2. Cloning of human tissues will help regenerate tissues in burns, help in organ replacements and eliminate the problem of immune reaction. This will eliminate the use of suppressive drugs.

 

3. In an emergency, cloning of a person's DNA can be done to make skin tissues as well as muscle tissues to help in processes such as Plastic surgery, reconstructive surgery and cosmetic surgery.

 

4. Cloning could be used to reverse heart attacks by taking cells from the healthy areas of the heart and planting them in the other areas.

 

5. Human cloning would make it possible for infertile parents to have children who have their DNA.

 

6. The dying process can be reversed by use of cloning technology.

 

The role of telomeres in deciding the lifespan of cloned animals is a topic of considerable debate.